Study Summary

We are currently running a multicentre study to determine the effectiveness of heparin coated or antibiotic impregnated CVCs compared with standard CVCs for preventing hospital acquired blood stream infection. 

Most children who are admitted to children’s intensive care units need to have their medicines given to them into their veins using a narrow tube called a central venous catheter or central line.  Very occasionally these catheters can cause infections in the blood and sometimes the catheter can get blocked by small blood clots. Some hospitals use catheters coated with antibiotics, which might prevent infections by killing bacteria, some use catheters coated with heparin – an anti-clotting medicine, and some use standard catheters. Most of the children’s intensive care units in this country use standard catheters.

We need to find out which catheter is better at reducing the risk of blood infections in children, or if there is no difference between them. The study will help hospitals decide which type of catheter to use for children admitted to intensive care in the future.  Twelve of the largest paediatric intensive care units in England have agreed to take part.

In this study children will be split into three groups by random chance and each group will receive a different type of catheter.

  • Standard catheter (not coated)
  • Catheter coated with Heparin
  • Catheter coated with antibiotics

Due to the nature of the study we have ethical approval to use a deferred consent process in emergency situations.  This means that in emergency situations the line will be inserted without any delay and consent will be sought from the child’s parent/legal guardian, and assent from the child where appropriate, to continue the study and incorporate the patient's record into the study.

Parents/legal guardian of a child needing elective surgery will be asked to consent prior to any study procedures.

 

 




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